GR 1144

Fluorescence in situ Hybridization

Jan 21, 2024
The Fluorescence in situ Hybridization (FISH) test is vital for cancer diagnosis, identifying specific genetic abnormalities in cells. It's particularly effective for breast cancer, detecting extra gene copies that guide treatment decisions. This genetic test's significance in cancer management highlights the role of advanced diagnostics in improving patient outcomes
Homed-Fluorescence in situ Hybridization

What is the Fluorescence in situ Hybridization (FISH) test?

The Fluorescence in situ Hybridization (FISH) test is a procedure that ‘maps’ genetic material in human cells, including specific genes or parts of genes. It’s useful for diagnosing certain types of cancer due to its ability to detect genetic abnormalities. For example, in breast cancer patients, the FISH test can show if cells have extra copies of the HER2/neu gene, affecting the therapeutic response to drugs like trastuzumab (Herceptin).

In 2018, a study at Mayo Clinic showed how the FISH test helps in cancer detection. This test discovered significant genetic abnormalities in a leukemia patient, determining her treatment. This example shows the importance of genetic tests in cancer and treatments that help recovery.

For a more detailed description, you can visit the original article on the Mayo Clinic website.

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Fluorescence in situ Hybridization



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